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亚专科： Gastrointestinal Pathology

更多的临床兴趣： Weibiao Cao studies the signal transduction pathways mediating contraction in
normal esophageal smooth muscle and the inflammation-associated changes in signaling that occur in
experimental esophagitis. His findings show that a low molecular weight phospholipase A2 (type I)
mediates cat and human in vitro lower esophageal sphincter tone by producing arachidonic acid, which
is metabolized to prostaglandin F2alpha and thromboxane A2. These arachidonic acid metabolites act
on receptors linked to Gi3 and Gq proteins to activate phospholipases, producing second messengers,
and maintaining LES tone.